Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
نویسندگان
چکیده
منابع مشابه
Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.
Rab geranylgeranyltransferase (RabGGTase or GGTase-II) catalyzes the post-translational prenylation of Rab proteins. Rab proteins are recognized as substrates only when they are complexed to Rab Escort Protein (REP). The classical model of prenylation complex assembly assumes initial formation of the Rab.REP binary complex, which subsequently binds to RabGGTase loaded with the isoprenoid donor ...
متن کاملRemodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.
PURPOSE To characterize in detail the disease expression in choroideremia (CHM), a blinding X-linked disease of the retina caused by loss-of-function mutations in Rab Escort Protein 1 (REP-1). CHM is readily diagnosed in the clinic and by molecular testing but has lacked an animal model to test hypotheses and therapeutics. The recent report of a mouse model for CHM prompts the need for reassess...
متن کاملInhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.
Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein geranylgeranyltransferase I (GGTase-I) and Rab geranylgeranyltransferase (RabGGTase) catalyze these modifications. In this work, we first describe the identification and characterization of small molecule inhibitors of GGTase-I (GGTI) with two novel scaffolds from a library consi...
متن کاملRab escort protein 1 ( REP 1 ) in intracellular traffic : a functional and pathophysiological overview Markus
requests to: Dr. rer. medic. Markus N. Preising, Dipl.Biol. (PhD) Department of Pediatric Ophthalmology, Strabismology and Ophthalmogenetics Klinikum, University of Regensburg 93042 Regensburg, Germany Tel: +49-941-944-9276 Fax: +49-941-944-9258 E-mail: markus.preising@klinik. uni-regensburg.de Abstract The intracellular distribution of proteins, compartments, substrates, and products is an act...
متن کاملInteraction analysis of prenylated Rab GTPase with Rab escort protein and GDP dissociation inhibitor explains the need for both regulators.
Prenylated Rab GTPases regulate intracellular vesicle trafficking in eukaryotic cells by associating with specific membranes and recruiting a multitude of Rab-specific effector proteins. Prenylation, membrane delivery, and recycling of all 60 members of the Rab GTPase family are regulated by two related molecules, Rab escort protein (REP) and GDP dissociation inhibitor (GDI). Biophysical analys...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2003
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(03)00044-3